Database : HANSEN Search on : HANSENOSTATICOS/USO TERAP [Subject descriptor] References found : 104 [refine] Displaying: 1 .. 20   in format [Detailed]

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Id: 19930 Author: Celik, Onur; Yalcin, Sinasi; Gok, Uzeyir; Yavrucuoglu, Emel; Ozturk, Ahmet; Akyol, Ali. Title: Auditory brain stem evoked potentials in patients with leprosy. Source: Int. J. Lepr;65(2):166-169, Jun. 1997. tab. Abstract: Nineteen, randomly selected male patients with lepromatous leprosy were evaluated electrophysiologically. All of these patients had long-standing disease and were treated with dapsone alone. There were statistically significant differences between the values obtained in this group of leprosy patients compared to 20 age-matched controls in auditory brain stem evoked potentials (ABEP). The findings are consistent with a pathologic process located mainly between the cochlear nucleus and the lateral lemniscus in the auditory brain stem pathways. It should be emphasized that our patients had long-standing disease which was treated with dapsone. ABEP could very well be different in leprosy patients diagnosed early and treated for relatively short periods with multidrug therapy. Brain stem evoked response audiometry may be useful for evaluating the possibility of brain stem involvement in leprosy. (AU)^ien. Descriptors: Hanseníase Virchowiana/diag Hanseníase Virchowiana/quimioter Hansenostáticos/uso terap Location: BR191.1

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Id: 19878 Author: Ji, Baohong. Title: Relapse of multibacillary leprosy after treatment with daily rifampin plus ofloxacin for four weeks. Source: Int. J. Lepr;66(3):391-391, Sept. 1998. . Descriptors: Hanseníase/quimioter Hansenostáticos/admin Hansenostáticos/uso terap Limits: Humanos Masculino Feminino Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3cor03.pdf / en Location: BR191.1

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Id: 19833 Author: Jacobson, Robert R. Title: Report of workshop on defining the disease and antibacterial therapy. Source: Int. J. Lepr;66(4):572-573, Dec. 1998. . Conference: Present in: International Leprosy Congress, 15, Beijing, 07-12 Sept. 1998. Descriptors: Hansenostáticos/uso terap Hanseníase/quimioter Hanseníase/prev Mycobacterium leprae/ef drogas Electronic Medium: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4repcur01.pdf / en Location: BR191.1

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Id: 18410 Author: Cottini, G. B Title: Contributo allo studio di tre casi di lepra con particolare ricuardo alla bacillemia ?- Source: s.l; s.n; 1933. 29p p. . Descriptors: HANSENIASE/compl HANSENIASE/quimioter HANSENIASE/microbiol HANSENIASE/terap ERITEMA NODOSO/etiol ERITEMA NODOSO/patol ERITEMA MULTIFORME/etiol ERITEMA MULTIFORME/patol SISTEMA NERVOSO PERIFERICO/les SISTEMA NERVOSO PERIFERICO/microbiol SISTEMA NERVOSO PERIFERICO/fisiopatol - HANSENOSTATICOS/uso terap  IODO/uso terap  OURO/uso terap  HELIOTERAPIA  MYCOBACTERIUM LEPRAE/isol  CELULAS SANGUINEAS/citol Limits: HUMANO Location: BR191.1; 01780/s

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Id: 18385 Author: Consigny, Sophie; Bentoucha, Abdelhalim; Bonnafous, Pascale; Grosset, Jacques; Ji, Baohong Title: Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice ..- Source: s.l; s.n; 2000. 3 p. tab. Abstract: Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae, measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP. Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slighthy more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae (AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/admin HANSENOSTATICOS/farmacol HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap MYCOBACTERIUM LEPRAE TESTES DE SENSIBILIDADE MICROBIANA/métodos DROGAS EM INVESTIGACAO/admin DROGAS EM INVESTIGACAO/anal DROGAS EM INVESTIGACAO/uso terap - BACTERICIDAS  QUIMIOTERAPIA COMBINADA  MYCOBACTERIUM LEPRAE/metab  MYCOBACTERIUM LEPRAE/fisiol  DAPSONA/uso terap  RIFAMPINA/uso terap  CLOFAZIMINA/uso terap  OFLOXACINO/uso terap  MINOCICLINA/uso terap  CLARITROMICINA/uso terap Limits: ESTUDO COMPARATIVO Location: BR191.1; 09311/s

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Id: 18384 Author: Biswas, S; Mondal, K. K Title: Multidrug therapy in leprosy can prevent relapse- a retrospective study ..- Source: s.l; s.n; 2002. 6 p. . Abstract: A retrospective study was done at the Leprosy Control Unit (LCU) in Durgapur of Burdwan district, West Bengal, to determine the relapse rate following multidrug therapy (MDT). A total of 1581 patients (1276 PB and 305 MB) completed MDT regimens during a period of 5 years as per WHO recommendations and National Leprosy Eradication Programme (NLEP) guidelines. The treated patients were kept under surveillance as per NLEP guidelines and searched for relapses. The results of MDT were compared with those of pre-MDT (monotherapy) era at the same centre (total: 405 patients; PB-373, MB-32) andalso with those of the Leprosy Clinic in Gopalpur (only dapsone was given to a total of 189 patients, PB-167, MB-22) Following monotherapy, the relapse rate was 10.06% at the Gopalpur Leprosy Clinic and 12.4% at the Dargapur LCU during the 2 years (PB) and 5 years (MB) of surveillance, whereas following MDT no relapse case was encountered both in PB and MB cases during the surveillance periods recommended by WHO. The results of this study are comparable with those of ohter studies. Though a few studies showed relapses during long-term surveillance beyond the periods recommended by WHO, it is once again established that MDT can prevent relapse in leprosy (AU). Descriptors: HANSENIASE/quimioter HANSENIASE/epidemiol HANSENIASE/prev RECIDIVA/prev - HANSENOSTATICOS/admin  HANSENOSTATICOS/hist  HANSENOSTATICOS/normas  HANSENOSTATICOS/uso terap  CLOFAZIMINA/uso terap  DAPSONA/uso terap  RIFAMPINA/uso terap Limits: ESTUDO COMPARATIVO HUMANO Location: BR191.1; 09310/s

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Id: 18281 Author: Hertaing, R. de; Coutejore, J Title: La lepre aujourd'hui: conceptions recentes de la lutte contre la lepre ..- Source: Kangu; s.n; s.d. 40 p. ilus, mapas. Descriptors: HANSENIASE DIMORFA/compl HANSENIASE DIMORFA/diag HANSENIASE VIRCHOWIANA/compl HANSENIASE VIRCHOWIANA/diag HANSENIASE TUBERCULOIDE/compl HANSENIASE TUBERCULOIDE/diag HANSENIASE/clas HANSENIASE/compl HANSENIASE/diag HANSENIASE/hist HANSENIASE/imunol HANSENIASE/microbiol HANSENIASE/prev HANSENIASE/terap HANSENIASE/transm HANSENOSTATICOS/admin HANSENOSTATICOS/uso terap HANSENIASE/epidemiol - EDUCACAO EM SAUDE/rec hum  EDUCACAO EM SAUDE/métodos  EDUCACAO EM SAUDE/org  EDUCACAO EM SAUDE/tend Limits: HUMANO Location: BR191.1; 00456/s

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Id: 18280 Author: Ustianowski, Andrew P; Lockwood, Diana N. J Title: Leprosy: current diagnostic and treatment approaches ..- Source: s.l; s.n; 2003. 7 p. . Abstract: PURPOSE OF REVIEW: Leprosy remains an important problem globally and leprosy patients may present to physicians outside leprosy endemic areas. We review the recent biological and clinical advances in leprosy. RECENT FINDINGS: Sequencing the genome has been a major biological advance and will open up new possibilities for research. The three cardinal criteria (anaesthetic skin patches, thickened nerves and acid-fast bacilli in skin smears) have not yet been bettered. Multidrug therapy for leprosy is highly effective with low relapse rates though the optimal duration of therapy for multibacillary patients is unclear. Nerve damage remains a significant problem (in some series only 50% responding to steroid therapy). New treatments for leprosy reactions are needed. Stigma remains a problem but is being combated by patient groups. SUMMARY: Far from being eliminated as a public health problem, leprosy still causes a considerable long-term morbidity in both the developing and developed world. New treatments for leprosy reactions are needed and the optimal length of multidrug therapy required further research. (AU). Descriptors: HANSENIASE/clas HANSENIASE/compl HANSENIASE/diag HANSENIASE/terap MYCOBACTERIUM LEPRAE/imunol MYCOBACTERIUM LEPRAE/patogen QUIMIOTERAPIA COMBINADA - HANSENOSTATICOS/admin  HANSENOSTATICOS/uso terap  INFECCAO/compl  INFECCAO/etiol  SINDROME DE IMUNODEFICIÊNCIA ADQUIRIDA/compl Limits: HUMANO Location: BR191.1; 00356/s

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Id: 18213 Author: Mathew, D; Kishore, B. Nanda ; Shwethadri, G. K; Sukumar; Shetty, N. J Title: An evaluation of clinical and histopathological status in paucibacillary leprosy patients after completion of sixed duration therapy ..- Source: s.l; s.n; 2004. 8 p. tab. Abstract: The presente study was carried out involving 25 patients with paucibacillary leprosy who attended the outpatient department of dermatology of Father Muller's Medical College Hospital during the period January 2001 to March 2002. All the patients were examined clinically and histopathologically at the beginning and at the end of six months of MDT and relevant data recorded. Clinicopathological correlation with histopathological classification before MDT was 72% and 68% at the end of MDT in our study. At the end of treatment 4 (16%) cases were clinically active and 8 (32%) were histopathologically active. The study showed that active cases were siginificantly reduced as a result of MDT, both clinically and histopatologically. The histopathological activity that outlasts MDT may be due to the bacillary fragments that persist; but clincial activity coupled with histopathological activity seen in 2 patients at the end of 6 months of MDT was possibly an indicator of relapse and these patients and similar others need to be follewed up for a longer duration. Is this study, resolution of granuloma and clinical activity after completion of MDT were assessed (AU). Descriptors: HANSENIASE TUBERCULOIDE/compl HANSENIASE TUBERCULOIDE/patol HANSENIASE TUBERCULOIDE/fisiopatol HANSENIASE TUBERCULOIDE/terap RESULTADO DE TRATAMENTO HANSENOSTATICOS/admin HANSENOSTATICOS/farmacol HANSENOSTATICOS/uso terap QUIMIOTERAPIA COMBINADA - HANSENIASE/clas  HANSENIASE/diag  HANSENIASE/terap Limits: HUMANO Location: BR191.1; 08999/s

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Id: 18142 Author: Martin M Fisher; William Mccann; Arthur Michele Title: Foot ulcers in hansens Disease ..- Source: New York; s.n; 1964. 5 p. ilus. Abstract: In this report we present the results of our observations of 2 patients in the New York City area with ulcers on the plantar surface. Our purpose in describing these cases is to emphasize the need to consiuder hansens diase in the diagnosis of ulcers of the foot. We have been able to heal theserefractory ulcers by the use of sodium sulfoxone (Diasone sodium), the specific for hansens disease. A critical evaluation of the newr technics for confirmation of this diagnosis is presented. The awareness of the existence of hansens disease helps to differentiate it from the more common causes of leg and foot ulcers in peripheral vascular diseases. Thus there is a need to evaluate all lower extremity ulcers with specifc diagnostic tests, such as blood sugar for diabetes cryoglobulins for cryoglobulinemia ulcer biopsy for epithelioma and a complete blood count bone marrow biopsy and coombs test for sickle cell anemia cooleys anemia and hemolytic anemia. A careful history and accurate physical examination can usually differentiate a thromboangiitis obliterans ulcer from that of peripheral arteriosclerosis obliterans. Similarly the ulcer of varicose veins is differentiated from that of diabetic neuritis by physival evaluation and the postphlebilitic ulcer is differenbtiated from that of choronic lymphedema by lymphangiography. The following are 2 typical cases of foot ulcers due to hansens disease found in the New York City area. (AU). Descriptors: HANSENIASE/compl HANSENIASE/terap ULCERA DO PE/compl ULCERA DO PE/diag ULCERA DO PE/etiol ULCERA DO PE/terap - HANSENOSTATICOS/uso terap  NEURITE/diag  NEURITE/terap Limits: HUMANO Location: BR191.1; 01142/s

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Id: 18103 Author: Desforges, J. F; Thayer, W. W; Dawson, J. P Title: Hemolytic anemia induced by sulfoxone therapy, with investigations into the mechanisms of its production ?- Source: Boston; s.n; 1960. 5p p. ilus. Abstract: A case report is presented of a patient in whom clinical evidence of hemolytic anemia with methemoglobinemia developed upon increasing the dosage of sulfoxone which he was receiving for Hansen's disease. Administration of the drug was withdrawn for six weeks, after which studies were made with the use of radioactive iron to demosntrate the hemolytic effect of sulfoxone. By means of tagging cells of a single age group, it was shown that the suceptibility to hemolysis was related to cell age, and it was only after the red cells had been in the circulation for approximately fifty days that they were subject to the hemolytic effects of this drug. No significant biochemical defect could be demonstrated in the erythrocytes of this patient. However, the decline in activity of glucose-6-phosphate dehydrogenase and glutathione reductase in the aging red cell and the reported sensitivity to this drug of patients with red cell deficiency of glucose-6-phosphate dehydrogenase suggest that the hemolytic mechanism is related to this enzyme system. The case demonstrates that drug-induced hemolytic anemia of this type may occur without demonstrable enzymatic defect of the erythrocytes. The observation that patients appear to compensate for the hemolytic anemia and methemoglobinemia if maintained on this drug may be explained by the fact that the older cells containing less adequate enzyme systems are removed from the circulation and an equilibrium is maintained by increased production of red cells with a shorter age span. Descriptors: HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/sangue HANSENOSTATICOS/uso terap ANEMIA HEMOLITICA/ind quim ANEMIA HEMOLITICA/diag ANEMIA HEMOLITICA/etiol - HANSENIASE/clas  HANSENIASE/compl  HANSENIASE/diag  HANSENIASE/terap Limits: RELATO DE CASO Location: BR191.1; 00720/s

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Id: 18100 Author: Browne, S. G Title: La lèpre: maladie à manifestations diverses et à problèmes multiples ?- Source: s.l; s.n; 1964. 10p p. . Descriptors: HANSENIASE/clas HANSENIASE/compl HANSENIASE/diag HANSENIASE/epidemiol HANSENIASE/etiol HANSENIASE/imunol - HANSENOSTATICOS/ef rad  HANSENOSTATICOS/uso terap  PRECONCEITO  ISOLAMENTO SOCIAL Limits: HUMANO Location: BR191.1; 00517/s

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Id: 17546 Author: Diorio, Suzana Madeira; Manini, Marli Izabel Penteado; Trino, Lazara Moreira; Sartori, Beatriz Gomes Carreira; Opromolla, Diltor Vladimir Araujo. Title: Resistance to dapsone and rifampin in Mycobacterium leprae isolated from leprosy patients of Sao Paulo State. Source: Hansen. int;30(1):15-18, Jan-Jun 2005. tab. Abstract: In 1981, reports of resistance to dapsone and rifampin led WHO to recommend multidrugtherapy in leprosy treatment. One of its main goals is preventing the selection of drug-resistant strains of mutant bacteria. Dapsone was the first drug which was experimentally proved to induce resistance; this became possible only after the mouse footpad inoculation technique was standardized, in 1960. There are some important criteria to suspect the existence of resistance, such as: relapses in multibacillary patients already treated or undergoing treatment or unsatisfactory clinical response. Our study aimed at detection of dapsone and rifampin resistant strains among 40 treated patients with clinical signs of relapse, from different cities of São Paulo State and its capital, employing the mouse footpad inoculation. We detected dapsone resistant bacilli in 11 cases. Among them, 5 showed total resistance, 1 intermediary resistance and 5 partial resistance. Rifampin resistant bacilli were detected in only two cases. We did not detect any case of multiple...(AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/uso terap MYCOBACTERIUM LEPRAE/ef drogas - HANSENIASE/PATOL  MODELOS ANIMAIS Electronic Medium: Internet Location: BR191.1

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Id: 17541 Author: Diorio, Suzana Madeira; Manini, Marli Izabel Penteado; Trino, Lazara Moreira; Sartori, Beatriz Gomes Carreira; Opromolla, Diltor Vladimir Araujo. Title: Resistencia a dapsona e rifampicina em Mycobacterium leprae isolado de pacientes portadores de hanseniase no Estado de Sao paulo / Resistance to dapsone and rifampin in Mycobacterium leprae isolated from leprosy patients of Sao Paulo Source: Hansen. int;30(1):09-14, Jan-Jun 2005. tab. Abstract: Os relatos de resistencia e rifampicina fizeram com que a Organizaçao Mundial de Saude preconizasse, 1981, a poliquimioterapia para o tratamento da hanseniase. A prevençao da seleçao de cepas mutantes resistentes as drogas e um de seus principais objetivos. A dpsona foi a primeira droga a ter comprovação experimental de resistencia e isto so foi possivel depois que a tecnica de inoculaçao do bacilo em coxim plantar de camundongos foi padronizado em 1960. Criterios importantes a serem considerados para se suspeitar de resistencia seriam recidivas em pacientes multibacilares ja tratado, ou em tratamento, ou resposta clinica insatisfatoria. Nosso estudo teve por objetivo detectar cepas resistentes a dapsona e rifampicina entre 40 pacientes tratados com sinais clinicos de recidiva, procedentes de cidades do Estado de Sao paulo e capital, utilizando a tecnica de inoculaçao do em coxim plantar de camundongos. Foram observados bacilos resistentes a dapsona em 11 casos, sendo 05 de resistencia total, 01 intermediario e 05 parcial. Bacilos resistente a rifampicina foram observados em apenas 02 casos. Nao se observou nenhum caso de resistencia multipla. O alto indice obtido de resistencia a dapsona, provavelmente e decorrencia de muitos anos de monoterapia sulfonica ou de seus derivados. No caso da rifampicina, provavelmente a droga foi utilizada de forma irregular, em monoterapia ou aind, o paciente pode ter utilizado-a previamente para tratar outra molestia....(AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/uso terap MYCOBACTERIUM LEPRAE/ef drogas - HANSENIASE/patol  MODELOS ANIMAIS Electronic Medium: Internet Location: BR191.1

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Id: 17468 Author: Trautman, J. R Title: The management of leprosy and its complications ?- Source: Louisiana; s.n; 1965. 10p p. . Descriptors: HANSENIASE/compl HANSENIASE/quimioter HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/uso terap ERITEMA NODOSO/quimioter NEURITE/quimioter NEURITE/fisiopatol AMILOIDOSE/dietoter Limits: RELATO DE CASO Location: BR191.1; 01106/d.a

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Id: 17440 Author: Browne, S. G Title: The chemotherapy of leprosy ?- Source: s.l; s.n; s.d. 5p p. . Descriptors: HANSENIASE/dietoter HANSENIASE/quimioter HANSENOSTATICOS/farmacocin HANSENOSTATICOS/uso terap SULFONAS/ef adv SULFONAS/farmacol SULFONAS/farmacocin SULFONAS/tox SULFONAS/uso terap Limits: RELATO DE CASO Location: BR191.1; 01105/d.a

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Id: 17211 Author: Roy, A. T. Title: Diaminodiphenylsulphone in leprosy. Source: Lepr Ind;24(3):130-132, july, 1952. tab. Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/uso terap SULFONAS/admin Location: BR191.1

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Id: 17210 Author: S, B. B. M. Dharmendra; Chatterjee, K. R. Title: Thiosemicarbazone in the treatment of leprosy. Source: Lepr Ind;24(3):93-, july, 1952. tab. Abstract: (I) The previous work with thiosemicarbazone in the treatment of leprosy is summarised. (2) Siocarbazone brand of thiosemicarbazone has been used in 52 cases of leprosy, 9 untraeded neural cases, 27 untreated lepromatous cases and 16 previously treated lepromatous cases, 15 with sulphones, and I with hydnocarpus oil. The duration of treatment has from 2 months to 16 months with an average of I0 months. (3) The patients have stood the drug well and there has been satisfactory clinical and bacteriological response. In addition to usual therapeutic affects, special features with thiosemicarbazone treatment have been the complete or partial restoration of sensation in the anaesthetic patches and in the limbs with polyneuritic type of anaesthesia, replacement of deseased nails by new ones, and growth of new hair in depilated areas. Considering the short period of treatment those features are rather remarkable. (4) In the toxicity of thiosemicarbazone seems to be less than that of the sulphones specially in relation to its effect on the haemopoietic system. However, the thiosemicarbazone is not as free from toxicity as described by some workers eho have used it in leprosy. A special kind of toxicity which indicates specific intolerance has been noticed and this has been manifested by sudden rise of temperature even after small doses of the drug (AU). Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/admin HANSENOSTATICOS/ef adv HANSENOSTATICOS/farmacol HANSENOSTATICOS/tox HANSENOSTATICOS/uso terap Location: BR191.1

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Id: 17126 Author: S, B. B. M. Dharmendra. Title: The use of hydnocarpus oil in the treatment of leprosy. Source: Lepr Ind;16(2):54-58, apr., 1944. . Descriptors: HANSENIASE/quimioter HANSENOSTATICOS/uso terap HANSENOSTATICOS/hist Location: BR191.1

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Id: 17125 Author: Anon. Title: Erythrocyte sedimention test. Source: Lepr Ind;16(2):51-53, apr., 1944. . Descriptors: HANSENIASE/sangue HANSENIASE/quimioter HANSENOSTATICOS/uso terap CHAULMOOGRA HOSPITAIS DE DERMATOLOGIA SANITARIA DE PATOLOGIA TROPICAL/hist Location: BR191.1

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